This is a non-nicotine, prescription-strength medication to help you quit smoking. While it's unclear exactly how ZYBAN works, ZYBAN is thought to work on the chemicals in the brain. It helps reduce the urge to smoke, and lessens symptoms of withdrawal. Your chances of quitting with ZYBAN greatly depend on your commitment to quitting.

ZYBAN helps reduce your urge to smoke and can make quitting bearable. You may continue to smoke after you begin to take ZYBAN. Then you and your health care professional will set a quit date, usually 8 to 14 days after your first dose of ZYBAN. When your quit date arrives, you stop smoking and continue taking ZYBAN.

Before taking Zyban, smokers want to know what Zyban will do to make quitting easier. According to the results reported during clinical trials, "treatment with ZYBAN reduced withdrawal symptoms compared to placebo. Reductions on the following withdrawal symptoms were most pronounced: irritability, frustration, or anger; anxiety; difficulty concentrating; restlessness; and depressed mood or negative affect. Depending on the study and the measure used, treatment with ZYBAN showed evidence of reduction in craving for cigarettes or urge to smoke compared to placebo."

• Quitting with Zyban is about twice as likely as with placebo at 3 months;
• About 1.5 times success rate than with placebo at 1 year;
• Bupropion has similar success to nicotine replacement, and lower than varenicline.